Publications

All Publications

https://www.ncbi.nlm.nih.gov/pubmed/?term=Lawlor%20ER%5BAuthor%5D&cauthor=true&cauthor_uid=24590121

Recent Publications

• Jiménez, JA, Lawlor, ER, and Lyssiotis, CA. Amino Acid Metabolism in Primary Bone Sarcomas. Front. Oncol. 2022 Oct 05; doi:10.3389/fonc.2022.1001318.

• Apfelbaum, AA, Wu, F, Hawkins, AG, Magnuson, B, Jiménez, JA, Taylor, SD, Wrenn, ED, Waltner, O, Pfaltzgraf ER, Song, JY, Hall, C, Wellik, DM, Ljungman, M, Furlan, S, Ryan RJH, Sarthy, J, Lawlor, ER. EWS::FLI1 and HOXD13 Control Tumor Cell Plasticity. Clin Cancer Res. 2022 Oct 14;28(20): 4466-4478. doi: 10.1158/1078-0432.CCR-22-0384.

• Jiménez JA, Apfelbaum AA, Hawkins AG, Svoboda LK, Kumar A, Ruiz RO, Garcia AX, Haarer E, Nwosu ZC, Bradin J, Purohit T, Chen D, Cierpicki T, Grembecka J, Lyssiotis CA, Lawlor ER. EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing sarcoma. Mol Cancer Res. 2021 Mar 19;19(7):1182-1195. doi: 10.1158/1541-7786.MCR-20-0679.

• Hawkins AG, Pedersen EA, Treichel S, Temprine K, Sperring C, Read JA, Magnuson B, Chugh R,  Lawlor ER. Wnt/β-catenin-activated Ewing sarcoma cells promote the angiogenic switch. JCI Insight. 2020 Jul 9;5(13):e135188. doi: 10.1172/jci.insight.135188.

• Hawkins AG, Julian CM, Konzen S, Treichel S, Lawlor ER, Bailey KM. Microenvironmental Factors Drive Tenascin C and Src Cooperation to Promote Invadopodia Formation in Ewing sarcoma.Neoplasia. 2019 Oct;21(10):1063-1072. doi: 10.1074/j.neo.2019.08.001 Epub 2019 Sep 13. PubMed PMID: 31521948; PubMed Central PMCID: PMC6745492.
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• Pfaltzgraff ER, Apfelbaum A, Kassa AP, Song JY, Jiang W Suhan TK, Wellik DM, Lawlor ER. Anatomic Origin of Osteochondrogenic Progenitors Impacts Sensitivty to EWS-FLI1-induced Transformation. Cancer. 2019 Mar6; 11(3).pii: E313.  doi: 10.3390/mcp.cancers11030313. PubMed PMID: 30845695; PubMed Central PMCID: PMC6468467.

• Hawkins AG, Basrur V, da Veiga Leprevost F, Pedersen E, Sperring C, Nesvizhskii AI, Lawlor ER. The Ewing Sarcoma Secretome and Its Response to Activation of Wnt/beta-catenin Signaling. Mol Cell Proteomics. 2018 May;17(5):901-912. doi: 10.1074/mcp.RA118.000596. Epub 2018 Jan 31. PubMed PMID: 29386236; PubMed Central PMCID: PMC5930412.
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•  Svoboda LK, Teh SSK, Sud S, Kerk S, Zebolsky A, Treichel S, Thomas D, Halbrook CJ, Lee HJ, Kremer D, Zhang L, Klossowski S, Bankhead AR, Magnuson B, Ljungman M, Cierpicki T, Grembecka J, Lyssiotis CA, Lawlor ER. Menin regulates the serine biosynthetic pathway in Ewing sarcoma. J Pathol. 2018 Apr 19. doi: 10.1002/path.5085. [Epub ahead of print] PubMed PMID: 29672864.
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•  Gorthi A, Romero JC, Loranc E, Cao L, Lawrence LA, Goodale E, Iniguez AB, Bernard X, Masamsetti VP, Roston S, Lawlor ER, Toretsky JA, Stegmaier K, Lessnick SL, Chen Y, Bishop AJR. EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma. Nature. 2018 Mar 15;555(7696):387-391. doi: 10.1038/nature25748. Epub 2018 Mar 7. PubMed PMID: 29513652.
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•  Newman EA, Chukkapalli S, Bashllari D, Thomas TT, Van Noord RA, Lawlor ER, Hoenerhoff MJ, Opipari AW, Opipari VP. Alternative NHEJ pathway proteins as components of MYCN oncogenic activity in human neural crest stem cell differentiation: implications for neuroblastoma initiation. Cell Death Dis. 2017 Dec 13;8(12):3208. doi: 10.1038/s41419-017-0004-9. PubMed PMID: 29238067; PubMed Central PMCID: PMC5870584.
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•  VAN Noord RA, Thomas T, Krook M, Chukkapalli S, Hoenerhoff MJ, Dillman JR, Lawlor ER, Opipari VP, Newman EA. Tissue-directed Implantation Using Ultrasound Visualization for Development of Biologically Relevant Metastatic Tumor Xenografts. In Vivo. 2017 Sep-Oct;31(5):779-791. PubMed PMID: 28882943; PubMed Central PMCID: PMC5656850.
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•  Svoboda LK, Bailey N, Van Noord RA, Krook MA, Harris A, Cramer C, Jasman B, Patel RM, Thomas D, Borkin D, Cierpicki T, Grembecka J, Lawlor ER. Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL1 and menin.Oncotarget. 2017 Jan 3;8(1):458-471. doi: 10.18632/oncotarget.13444. PubMed PMID: 27888797; PubMed Central PMCID: PMC5352134.
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•  Haak AJ, Appleton KM, Lisabeth EM, Misek SA, Ji Y, Wade SM, Bell JL, Rockwell CE, Airik M, Krook MA, Larsen SD, Verhaegen M, Lawlor ER, Neubig RR. Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma. Mol Cancer Ther. 2017 Jan;16(1):193-204. doi: 10.1158/1535-7163.MCT-16-0482. Epub 2016 Nov 11. PubMed PMID: 27837031; PubMed Central PMCID: PMC5555736.
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•  Gray F, Cho HJ, Shukla S, He S, Harris A, Boytsov B, Jaremko Ł, Jaremko M, Demeler B, Lawlor ER, Grembecka J, Cierpicki T. BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization. Nat Commun. 2016 Nov 9;7:13343. doi: 10.1038/ncomms13343. PubMed PMID: 27827373; PubMed Central PMCID: PMC5105191.
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•  Bailey KM, Airik M, Krook MA, Pedersen EA, Lawlor ER. Micro-Environmental Stress Induces Src-Dependent Activation of Invadopodia and Cell Migration in Ewing Sarcoma. Neoplasia. 2016 Aug;18(8):480-8. doi: 10.1016/j.neo.2016.06.008. PubMed PMID: 27566104; PubMed Central PMCID: PMC5018098.
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•  Evelyn CR, Lisabeth EM, Wade SM, Haak AJ, Johnson CN, Lawlor ER, Neubig RR. Small-Molecule Inhibition of Rho/MKL/SRF Transcription in Prostate Cancer Cells: Modulation of Cell Cycle, ER Stress, and Metastasis Gene Networks. Microarrays (Basel). 2016 May 28;5(2). pii: E13. doi: 10.3390/microarrays5020013. PubMed PMID: 27600078; PubMed Central PMCID: PMC5003489.
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